Skin manifestations of systemic disease are wide, varied, specific and nonspecific. Generalised pruritus and cutaneous vasculitis are more common cutaneous presentations where an underlying systemic disease may be present and will influence management. 

– Generalised Pruritus

– Erythema Nodosum

– Cutaneous Vasculitis

– Connective Tissue Disorders

In certain chronic diseases such as connective tissue disease and chronic liver disease, there are characteristic cutaneous findings. Internal malignancies such as multiple myeloma may present with distinctive cutaneous findings, which need to be recognised to institute a search for the underlying neoplasm. The skin has the potential to provide a window into the patient and aid in the diagnosis of diseases of all organ systems.

The skin communicates with the body, often showing the first signs and/or symptoms of an internal disease, which may be the only expressions of systemic disorders.